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Product Description

Similac Pro-Advance* with 2’-FL human milk oligosaccharide (HMO) is complete nutrition designed to strengthen your baby’s immune system, from the #1 infant formula brand for immune support. It has our exclusive blend of DHA, lutein, and vitamin E to help support baby’s brain and eye development.

* Not for infants or children with galactosemia.

  • 2’-FL HMO FOR IMMUNE SUPPORT: Similac Pro-Advance has 2’-FL HMO, a prebiotic that helps strengthen the immune system to be more like the breastfed infant than ever before
  • SUPPORTS BRAIN & EYE DEVELOPMENT: Features our exclusive blend of DHA, lutein, and vitamin E, ingredients found in breast milk that are important for helping to support baby’s brain and eye development
  • PROMOTES STRONG BONES: Has no palm olein oil to promote excellent calcium absorption for strong bones
  • TRUSTED BRAND: Similac is the #1 infant formula brand chosen by parents§
  • NO ARTIFICIAL GROWTH HORMONES & NON-GMO: Similac is the first leading infant formula brand with no artificial growth hormones. Similac Pro-Advance contains ingredients that are not genetically engineered

* Not for infants or children with galactosemia.
Not from human milk.
Based on pediatrician recommendations.
§ Total US infant formula, all outlets as of 6/2020, Nielsen data.
No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows.
Ingredients not genetically engineered.

Ingredients & Nutrition

Allergen Statement

Contains milk and soy ingredients.

Ingredients

Water, Nonfat Milk, Lactose, High Oleic Safflower Oil, Soy Oil, Coconut Oil, Whey Protein Concentrate. Less than 0.5% of: C. Cohnii Oil, M. Alpina Oil, 2'-Fucosyllactose, Short-chain Fructooligosaccharides, Beta-Carotene, Lutein, Ascorbic Acid, Soy Lecithin, Monoglycerides, Potassium Citrate, Calcium Carbonate, Potassium Chloride, Carrageenan, Ferrous Sulfate, Magnesium Chloride, Choline Chloride, Choline Bitartrate, Taurine, Inositol, Calcium Phosphate, Zinc Sulfate, Potassium Phosphate, d-Alpha-Tocopheryl Acetate, Niacinamide, Calcium Pantothenate, L-Carnitine, Vitamin A Palmitate, Copper Sulfate, Thiamine Hydrochloride, Riboflavin, Pyridoxine Hydrochloride, Folic Acid, Manganese Sulfate, Phylloquinone, Biotin, Sodium Selenate, Vitamin D3, Vitamin B12, Salt, Potassium Iodide, Potassium Hydroxide, and Nucleotides (Adenosine 5’-Monophosphate, Cytidine 5’-Monophosphate, Disodium Guanosine 5’-Monophosphate, Disodium Uridine 5’-Monophosphate).

Serving Size: 100 Cal (5 fl oz)

Nutrient Data

Nutrient Data

Amount per serving
% Daily Value*
Calories
100
 
Volume, mL
148
 
Protein, g
2.07
 
Fat, g
5.4
 
Carbohydrate, g
11
 
Water, g
133
 
Linoleic Acid, mg
1000
 

Vitamins

Amount per serving
% Daily Value*
Vitamin E, IU
1.5
 
Vitamin K, mcg
8
 
Thiamin (Vitamin B1), mcg
100
 
Riboflavin (Vitamin B2), mcg
150
 
Vitamin B6, mcg
60
 
Vitamin B12, mcg
0.25
 
Niacin, mcg
1050
 
Folic Acid (Folacin), mcg
15
 
Pantothenic Acid, mcg
450
 
Biotin, mcg
4.4
 
Vitamin C (Ascorbic Acid), mg
9
 
Choline, mg
24
 
Inositol, mg
24
 
Vitamin A, IU
300
 
Vitamin D, IU
60
 

Minerals

Amount per serving
% Daily Value*
Calcium, mg
78
 
Calcium, mEq
3.9
 
Phosphorus, mg
42
 
Magnesium, mg
6
 
Iron, mg
1.8
 
Zinc, mg
0.75
 
Manganese, mcg
5
 
Copper, mcg
90
 
Iodine, mcg
15
 
Selenium, mcg
2
 
Sodium, mg
24
 
Sodium, mEq
1
 
Potassium, mg
105
 
Potassium, mEq
2.7
 
Chloride, mg
65
 
Chloride, mEq
1.8
 

Serving Size: 1000 mL (1.1 QT)

Nutrient Data

Nutrient Data

Amount per serving
% Daily Value*
Calories
676
 
Volume, mL
1000
 
Protein, g
13.99
 
Fat, g
36.49
 
Carbohydrate, g
74.32
 
Water, g
899
 
Linoleic Acid, mg
6757
 

Vitamins

Amount per serving
% Daily Value*
Vitamin E, IU
10.1
 
Vitamin K, mcg
54.1
 
Thiamin (Vitamin B1), mcg
676
 
Riboflavin (Vitamin B2), mcg
1014
 
Vitamin B6, mcg
405
 
Vitamin B12, mcg
1.69
 
Niacin, mcg
7095
 
Folic Acid (Folacin), mcg
101.4
 
Pantothenic Acid, mcg
3041
 
Biotin, mcg
29.7
 
Vitamin C (Ascorbic Acid), mg
60.8
 
Choline, mg
162.2
 
Inositol, mg
162.2
 
Vitamin A, IU
2027
 
Vitamin D, IU
405
 

Minerals

Amount per serving
% Daily Value*
Calcium, mg
527
 
Calcium, mEq
26.4
 
Phosphorus, mg
284
 
Magnesium, mg
40.5
 
Iron, mg
12.16
 
Zinc, mg
5.07
 
Manganese, mcg
33.8
 
Copper, mcg
608
 
Iodine, mcg
101
 
Selenium, mcg
14
 
Sodium, mg
162
 
Sodium, mEq
6.8
 
Potassium, mg
709
 
Potassium, mEq
18.2
 
Chloride, mg
439
 
Chloride, mEq
12.2
 
Reviews

Similac Pro-Advance Formula Reviews

Product Comparison

What is the difference between Similac Pro-Advance vs other formula types?

Similac Pro-Advance®* Infant Formula, with 2’-FL HMO for Immune Support, Non-GMO, Baby Formula, Powder, 1.45 lb

Similac Pro-Advance®* Infant Formula, with 2’-FL HMO for Immune Support, Non-GMO, Baby Formula, Powder, 1.45 lb

Similac Pro-Total Comfort™* Infant Formula, with 2’-FL HMO for Immune Support, Easy-to-Digest, Non-GMO, Baby Formula, Powder, 20.1 oz

Similac Pro-Total Comfort™* Infant Formula, with 2’-FL HMO for Immune Support, Easy-to-Digest, Non-GMO, Baby Formula, Powder, 20.1 oz

Pure Bliss™ by Similac®* Infant Formula, Modeled After Breast Milk, Non-GMO, Baby Formula, Powder, 24.7 oz (Case of 4)

Pure Bliss™ by Similac®* Infant Formula, Modeled After Breast Milk, Non-GMO, Baby Formula, Powder, 24.7 oz (Case of 4)

Similac® Advance®* Infant Formula with Iron, Baby Formula, Powder, 20.6 oz

Similac® Advance®* Infant Formula with Iron, Baby Formula, Powder, 20.6 oz

Description
First formula with 2’-FL HMO, designed to be closer than ever to breast milk
A gentle formula with 2’-FL HMO, an immune-nourishing prebiotic
Starts with fresh milk from grass-fed cows
Complete nutrition for your baby’s first year
Complete Nutrition for Infants
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Non-GMO*
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Has 2’-FL HMO for Immune Support
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Our Closest to Breast Milk
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For Fussiness & Gas Due to Lactose Sensitivity
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Starts with Fresh Milk from Grass-Fed Cows
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* Ingredients not genetically engineered. 

FAQs

What is the main difference between Similac Advance and Similac Pro-Advance with 2’-FL HMO?

Similac Pro-Advance has 2’-FL HMO (human milk oligosaccharide*), a unique immune-nourishing prebiotic. 

* Not from human milk.

What are the key ingredients in Similac Pro-Advance?

Similac Pro‐Advance was the first infant formula with 2’-FL HMO (2’‐fucosyllactose, a human milk oligosaccharide*), an immune-nourishing prebiotic that adds another layer to the already proven immune support from Similac.

Other key ingredients include:

  • Fructooligosaccharides
  • Nucleotides
  • DHA, lutein, and vitamin E
  • No palm olein oil for excellent calcium absorption

Additional features:

  • Non-GMO
  • Kosher, halal
* Not from human milk. 
 Ingredients not genetically engineered.

How do Similac Pro-Advance, Similac Pro-Sensitive, and Similac Pro-Total Comfort compare to other brands of baby formula?

Similac has been a trusted brand for over 90 years. Some other reasons to choose Similac Pro-Advance, Similac Pro-Sensitive, and Similac Pro-Total Comfort over other brands are because they:

  • Are the first baby formulas with 2’-FL HMO (human milk oligosaccharide*), a unique immune-nourishing prebiotic
  • No palm olein oil to promote excellent calcium absorption for strong bones
  • Have our exclusive blend of DHA, lutein, and vitamin E
  • Are from Similac, the first leading infant formula brand with no artificial growth hormones
* Not from human milk. 
 No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows.

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