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Product Description

Similac Pro-Total Comfort* is our most gentle formula with 2’-FL human milk oligosaccharide (2’-FL HMO), an immune-nourishing prebiotic like that found in breast milk that supports baby’s developing immune system. It’s an easy-to-digest formula delicate tummies and a good choice for babies who have difficulty tolerating other milk-based formulas.

* Not for infants or children with galactosemia.

  • LESS FUSSINESS & CRYING: Parents reported§ a significant reduction in fussiness, gas, and crying after just 1 day of feeding
  • GENTLE FORMULA + IMMUNE SUPPORT: Similac Pro-Total Comfort is our most gentle formula with 2’-FL HMO, a prebiotic that helps strengthen your baby’s immune system
  • SUPPORTS BRAIN & EYE DEVELOPMENT: Features our exclusive blend of DHA, lutein, and vitamin E, ingredients found in breast milk that are important for helping to support baby’s brain and eye development
  • PROMOTES STRONG BONES: Has no palm olein oil to promote excellent calcium absorption for strong bones
  • TRUSTED BRAND: Similac is the #1 infant formula brand chosen by parentsǁ
  • NO ARTIFICIAL GROWTH HORMONES & NON-GMO#: Similac is the first leading infant formula brand with no artificial growth hormones. Similac Pro-Total Comfort contains ingredients that are not genetically engineered

* Not for infants or children with galactosemia.
Not from human milk.
At significant levels.
§ After switching to Similac Pro-Total Comfort.
Total US infant formula, all outlets as of 6/2020, Nielsen data.
No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows.
# Ingredients not genetically engineered.

Ingredients & Nutrition

Allergen Statement

Contains milk ingredients.

Ingredients

Corn Maltodextrin, Whey Protein Hydrolysate, High Oleic Safflower Oil, Sugar, Soy Oil, Coconut Oil. Less than 2% of: C. Cohnii Oil, M. Alpina Oil, 2'-Fucosyllactose, Short-Chain Fructooligosaccharides, Beta-Carotene, Lutein, Lycopene, Calcium Citrate, Potassium Phosphate, Calcium Phosphate, Magnesium Chloride, Salt, Potassium Citrate, Ascorbic Acid, Choline Chloride, Sodium Citrate, Potassium Chloride, Calcium Hydroxide, Ferrous Sulfate, Taurine, m-Inositol, Choline Bitartrate, Zinc Sulfate, Ascorbyl Palmitate, L-Carnitine, Niacinamide, Mixed Tocopherols, d-Alpha-Tocopheryl Acetate, Calcium Pantothenate, Copper Sulfate, Vitamin A Palmitate, Thiamine Hydrochloride, Riboflavin, Pyridoxine Hydrochloride, Folic Acid, Manganese Sulfate, Phylloquinone, Potassium Iodide, Biotin, Sodium Selenate, Vitamin D3, Vitamin B12, Potassium Hydroxide, and Nucleotides (Adenosine 5’-Monophosphate, Cytidine 5’-Monophosphate, Disodium Guanosine 5’-Monophosphate, Disodium Uridine 5’-Monophosphate).

Serving Size: 100 Cal (5.3 fl oz, prepared as directed)

Nutrient Data

Nutrient Data

Amount per serving
% Daily Value*
Calories
100
 
Volume, mL
156
 
Protein, g
2.32
 
Fat, g
5.4
 
Carbohydrate, g
11
 
Water, g
141
 
Linoleic Acid, mg
1000
 

Vitamins

Amount per serving
% Daily Value*
Vitamin E, IU
1.5
 
Vitamin K, mcg
8
 
Thiamin (Vitamin B1), mcg
100
 
Riboflavin (Vitamin B2), mcg
160
 
Vitamin B6, mcg
63
 
Vitamin B12, mcg
0.26
 
Niacin, mcg
1100
 
Folic Acid (Folacin), mcg
16
 
Pantothenic Acid, mcg
470
 
Biotin, mcg
4.6
 
Vitamin C (Ascorbic Acid), mg
9
 
Choline, mg
24
 
Inositol, mg
4.5
 
Vitamin A, IU
300
 
Vitamin D, IU
60
 

Minerals

Amount per serving
% Daily Value*
Calcium, mg
105
 
Calcium, mEq
5.3
 
Phosphorus, mg
70
 
Magnesium, mg
6
 
Iron, mg
1.9
 
Zinc, mg
0.79
 
Manganese, mcg
5
 
Copper, mcg
95
 
Iodine, mcg
9
 
Selenium, mcg
2
 
Sodium, mg
46
 
Sodium, mEq
2
 
Potassium, mg
121
 
Potassium, mEq
3.1
 
Chloride, mg
68
 
Chloride, mEq
1.9
 

Serving Size: 1000 mL (Prepared as directed)

Nutrient Data

Nutrient Data

Amount per serving
% Daily Value*
Calories
643
 
Volume, mL
1000
 
Protein, g
14.92
 
Fat, g
34.72
 
Carbohydrate, g
70.7
 
Water, g
901
 
Linoleic Acid, mg
6429
 

Vitamins

Amount per serving
% Daily Value*
Vitamin E, IU
9.6
 
Vitamin K, mcg
51
 
Thiamin (Vitamin B1), mcg
643
 
Riboflavin (Vitamin B2), mcg
1029
 
Vitamin B6, mcg
405
 
Vitamin B12, mcg
1.67
 
Niacin, mcg
7072
 
Folic Acid (Folacin), mcg
103
 
Pantothenic Acid, mcg
3022
 
Biotin, mcg
29.6
 
Vitamin C (Ascorbic Acid), mg
58
 
Choline, mg
154
 
Inositol, mg
28.9
 
Vitamin A, IU
1929
 
Vitamin D, IU
386
 

Minerals

Amount per serving
% Daily Value*
Calcium, mg
675
 
Calcium, mEq
33.8
 
Phosphorus, mg
450
 
Magnesium, mg
39
 
Iron, mg
12.2
 
Zinc, mg
5.08
 
Manganese, mcg
32
 
Copper, mcg
611
 
Iodine, mcg
58
 
Selenium, mcg
13
 
Sodium, mg
296
 
Sodium, mEq
12.9
 
Potassium, mg
778
 
Potassium, mEq
20
 
Chloride, mg
437
 
Chloride, mEq
12.2
 
Reviews

Similac Pro-Total Comfort Formula Reviews

Product Comparison

What is the difference between Similac Pro-Total Comfort vs other formula types?

Similac Pro-Total Comfort™* Infant Formula, with 2’-FL HMO for Immune Support, Easy-to-Digest, Non-GMO, Baby Formula, Powder, 22.5 oz

Similac Pro-Total Comfort™* Infant Formula, with 2’-FL HMO for Immune Support, Easy-to-Digest, Non-GMO, Baby Formula, Powder, 22.5 oz

Similac Sensitive®* Infant Formula, for Fussiness & Gas Due to Lactose Sensitivity, Baby Formula, Powder, 20.1 oz

Similac Sensitive®* Infant Formula, for Fussiness & Gas Due to Lactose Sensitivity, Baby Formula, Powder, 20.1 oz

Similac® Alimentum® Hypoallergenic Infant Formula, for Food Allergies and Colic, Baby Formula Powder, 19.8-oz Can (Case of 4)

Similac® Alimentum® Hypoallergenic Infant Formula, for Food Allergies and Colic, Baby Formula Powder, 19.8-oz Can (Case of 4)

Similac Pro-Advance®* Infant Formula, with 2’-FL HMO for Immune Support, Non-GMO, Baby Formula, Powder, 20.6 oz

Similac Pro-Advance®* Infant Formula, with 2’-FL HMO for Immune Support, Non-GMO, Baby Formula, Powder, 20.6 oz

Description
A gentle formula with 2’-FL HMO, an immune-nourishing prebiotic
For fussiness and gas due to lactose sensitivity
For babies with food allergies and colic symptoms due to protein sensitivity
First formula with 2’-FL HMO, designed to be closer than ever to breast milk
Complete Nutrition for Infants
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Suitable for Lactose Sensitivity
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For Fussiness & Gas
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100% Partially Hydrolyzed Whey Protein for Easy Digestion
Selected
Has 2’-FL HMO for Immune Support
Selected
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Hypoallergenic for Cow’s Milk Allergy
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FAQs

What is the difference between Similac Pro-Total Comfort and Similac Pro-Sensitive?

Similac Pro-Sensitive has intact milk protein, while Similac Pro-Total Comfort has 100% whey protein that is partially hydrolyzed as an alternative to standard intact-protein, milk-based formulas. 

What’s the difference between Similac Pro-Advance, Similac Pro-Sensitive, Similac Pro-Total Comfort, and other Similac baby formulas?

Similac Pro‐Advance is our closest formula to breast milk. Similac Pro‐Advance, Similac Pro‐Sensitive, and Similac Pro-Total Comfort have 2’-FL HMO (human milk oligosaccharide*), a unique immune-nourishing prebiotic. Other Similac baby formulas also provide complete nutrition for babies, but it’s up to parents, along with their doctor, to choose which formula to feed their baby. Learn more 

* Not from human milk.

What does Similac Pro-Total Comfort help with?

Similac Pro-Total Comfort with 2’-FL HMO is an easy-to-digest, gentle baby formula. It’s designed for babies who have difficulty tolerating other milk-based formulas and mild tolerance symptoms, such as fussiness and gas due to lactose sensitivity.

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