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Similac® Formulas with 2’-FL HMO Are Inspired by Breast Milk

Similac Pro-Advance®, Similac Pro-Sensitive®, and Similac Pro-Total Comfort™ are the first Similac formulas with 2’-FL HMO,* a prebiotic like that found in most breast milk. 2’-FL HMO supports a baby’s immune system to be more like that of a breastfed infant.

Because you promise to give your baby a strong start—we make formulas that help you keep that promise.

Discover the Similac difference in Similac Pro-Advance, Similac Pro-Sensitive, and Similac Pro-Total Comfort.



  • 2’-FL HMO* for immune support

          A prebiotic that helps strengthen your baby’s immune system to be more like a breastfed infant than ever before1-3 

  • DHA, lutein, and vitamin E

         Also found in breast milk, these nutrients help support your baby’s brain & eye development

  • No Palm Olein Oil

        Similac is palm olein oil-free to support excellent calcium absorption and stronger bones

  • No Artificial Growth Hormones

        Similac formulas have no artificial growth hormones

  • Non-GMO

         Our products contain ingredients that are not genetically engineered

Choosing a Baby Formula with 2’-FL HMO*

Not all baby formulas are created equal. Watch our video to learn why Similac formula has the ingredients that matter most, including 2’-FL HMO, an ingredient naturally found in breast milk.


Have more questions about 2'-FL HMO?*

Learn more about the benefits of 2’-FL HMO in our FAQs.

See FAQs

* Not from human milk.
No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows.
Ingredients not genetically engineered.
References: 1. Goehring KC, et al. J Nutr. 2016;146(12):2559-2566. 2. Schaller JP, et al. Pediatr Res. 2004;56(6):883-890. 3. Buck RH, et al. Pediatr Res. 2004;56(6):891-900.

Find the Perfect Formula

Our products are made with your baby’s unique needs in mind. Choose from hypoallergenic, soy, and organic formulas, as well as other specialized nutrition options.

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The Promise of Similac

We promise to help keep your baby fed, happy, and healthy.

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Now you can switch to digital savings by phone on your favorite formulas—here’s how:

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